Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14241236 | 0.98 | ALDH1A1 (0.42) | ADRB2ADRB1ADRB3ALDH1A1MEN1 | |
| SCHEMBL28824160 | 0.98 | ADRB2 (0.40) | ADRB2ADRB1ADRB3ALDH1A1MEN1 | |
| SCHEMBL23141734 | 0.97 | ALDH1A1 (0.41) | ADRB2ADRB1ADRB3ALDH1A1MEN1 | |
| SCHEMBL29500422 | 0.97 | ALDH1A1 (0.41) | ADRB2ADRB1ADRB3ALDH1A1MEN1 | |
| SCHEMBL1296945 | 0.93 | PPARG (0.38) | ADRB2ADRB1ADRB3EPHX2PPARG | |
| SCHEMBL1298237 | 0.91 | PPARG (0.37) | PPARGRARBMAPT | |
| SCHEMBL1297561 | 0.91 | PPARG (0.37) | PPARGRARBMAPT | |
| SCHEMBL1297969 | 0.91 | PPARG (0.37) | PPARGRARBMAPT | |
| SCHEMBL21986996 | 0.91 | PPARG (0.37) | PPARGRARBMAPT | |
| SCHEMBL1296660 | 0.91 | PPARG (0.37) | PPARGRARBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268434-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074784-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-β PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |