Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979992 | 0.89 | SCN8A (0.36) | SCN8AALDH1A1MAPT | |
| SCHEMBL9087868 | 0.82 | SCN8A (0.34) | SCN8A | |
| SCHEMBL8556463 | 0.79 | HDAC1 (0.34) | SCN8AKDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL8824433 | 0.77 | SCN8A (0.38) | SCN8AKDM4EMAPTKCNH2 | |
| SCHEMBL8913750 | 0.76 | SCN8A (0.33) | SCN8AMAPTNPSR1KCNH2 | |
| SCHEMBL6977621 | 0.75 | GAA (0.37) | NPC1MAPTRAB9ANPSR1 | |
| SCHEMBL9089326 | 0.75 | SCN8A (0.36) | SCN8AKDM4E | |
| SCHEMBL6982022 | 0.74 | NR1I2 (0.47) | — | |
| SCHEMBL8824480 | 0.72 | SCN8A (0.38) | SCN8AKDM4EMAPTKCNH2 | |
| SCHEMBL8824442 | 0.72 | SCN8A (0.38) | SCN8AKDM4EALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759755-B1 | Thiadiazolylalkoxyphenyl derivatives, their preparation and their use anti-picornaviral agents | SANOFI SYNTHELABO (FR) | 2003-08-13 | — | — | EP | disclosed |
| US-5821257-A | Thiadiazoles and their uses as antipicornaviral agents | SANOFI (FR) | 1998-10-13 | — | — | US | disclosed |
| US-5750527-A | VIRICIDES | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| US-5650419-A | Thiadiazoles and their use as antipicornaviral agents | SANOFI, S.A. | 1997-07-22 | — | — | US | disclosed |
| EP-0759755-A4 | THIADIAZOLES AND THEIR USE AS ANTIPICORNAVIRAL AGENTS | SANOFI WINTHROP INC (US) | 1997-05-07 | — | — | EP | disclosed |
| EP-0759755-A1 | Thiadiazolylalkoxyphenyl derivatives, their preparation and their use anti-picornaviral agents | SANOFI WINTHROP, INC. (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5567719-A | Thiadiazoles and their use as antipicornaviral agents | STERLING WINTHROP, INC. (US) | 1996-10-22 | — | — | US | disclosed |
| WO-1995031198-A1 | THIADIAZOLES AND THEIR USE AS ANTIPICORNAVIRAL AGENTS | SANOFI WINTHROP, INC. (US) | 1995-11-23 | — | — | WO | disclosed |
| US-5453433-A | Viricides; antiseptics to decontaminate polio, rhino and coxsackie viruses | STERLING WINTHROP INC. (US) | 1995-09-26 | — | — | US | disclosed |