Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986888 | 0.94 | ADAM17 (0.43) | ADAM17CAPN1CAPN2HTTPSMB5 | |
| SCHEMBL6987004 | 0.80 | ADAM17 (0.42) | ADAM17HTTPSMB5 | |
| SCHEMBL6986296 | 0.80 | ADAM17 (0.44) | ADAM17CTSSCTSK | |
| SCHEMBL6982847 | 0.80 | ADAM17 (0.42) | ADAM17PSMB5 | |
| SCHEMBL6984118 | 0.76 | ADAM17 (0.45) | ADAM17PSMB5CTSKCTSB | |
| SCHEMBL6984386 | 0.74 | ADAM17 (0.44) | ADAM17PSMB5CTSSCTSK | |
| SCHEMBL6984132 | 0.74 | ADAM17 (0.42) | ADAM17HTTPSMB5 | |
| SCHEMBL6987013 | 0.74 | ADAM17 (0.42) | ADAM17PSMB5 | |
| SCHEMBL6982257 | 0.73 | ADAM17 (0.45) | ADAM17PSMB5CTSK | |
| SCHEMBL6988470 | 0.73 | ADAM17 (0.64) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |