Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.33 |
| ▸ | MMP3 | P08254 | 6/20 | 0.33 |
| ▸ | MMP7 | P09237 | 5/20 | 0.33 |
| ▸ | MMP1 | P03956 | 5/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984386 | 0.94 | ADAM17 (0.44) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6982847 | 0.88 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6987004 | 0.88 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6985273 | 0.84 | ADAM17 (0.59) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6987013 | 0.82 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6984132 | 0.82 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6981590 | 0.80 | ADAM17 (0.43) | ADAM17CTSSCTSK | |
| SCHEMBL6982700 | 0.79 | MMP1 (0.42) | MMP1MMP8MMP13CYP3A4CYP2D6 | |
| SCHEMBL6981905 | 0.78 | HRH4 (0.39) | CYP19A1HRH4CTSSCTSKCYP11B1 | |
| SCHEMBL6984118 | 0.77 | ADAM17 (0.45) | ADAM17MMP2MMP3MMP7MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |