Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.59 |
| ▸ | HTR1D | P28221 | 8/20 | 0.53 |
| ▸ | HTR1B | P28222 | 8/20 | 0.53 |
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | HTR2C | P28335 | 6/20 | 0.53 |
| ▸ | HTR7 | P34969 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969953 | 0.88 | HTR6 (0.56) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL14113985 | 0.88 | HTR6 (0.63) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL6975539 | 0.83 | HTR6 (0.62) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL6977685 | 0.80 | HTR6 (0.63) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL6980951 | 0.78 | HTR6 (0.80) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL3947243 | 0.76 | HTR6 (0.65) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL7532427 | 0.76 | HTR6 (0.64) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL1537914 | 0.74 | HTR6 (1.00) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL4311628 | 0.73 | HTR6 (0.98) | HTR6HTR1DHTR1BHTR1AHTR2C | |
| Oxalic Acid SCHEMBL5704881 | 0.71 | HTR6 (0.92) | HTR6HTR1DHTR1BHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | claimed |
| US-20030069233-A1 | Sulphonamide derivatives, process for their preparation, and their use as medicaments | SMITHKLINE BEECHAM P.L.C. | 2003-04-10 | — | — | US | claimed |
| US-6423717-B1 | NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-23 | — | — | US | claimed |
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069233-A1 | Sulphonamide derivatives, process for their preparation, and their use as medicaments | TPMT, MPST, STS | HTR6 1537/4885HTR1D 2870/4885HTR1B 1744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.