Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979874 | 0.92 | XDH (0.47) | XDHHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL6983466 | 0.87 | HSD17B10 (0.40) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL6978096 | 0.86 | HDAC1 (0.60) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL6978040 | 0.86 | HDAC1 (0.57) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL6973306 | 0.83 | HDAC1 (0.52) | XDHHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL6969616 | 0.82 | HDAC1 (0.55) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL6975923 | 0.81 | HDAC1 (0.47) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL6975037 | 0.79 | HDAC1 (0.45) | XDHHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL6979872 | 0.79 | GPR84 (0.42) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL6982543 | 0.78 | HDAC1 (0.62) | HDAC1HDAC6HDAC3HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |