SCHEMBL6981747

SCHEMBL6981747

CCCCS(=O)(=O)C(Nc1ccc2c(c1)CCCN2C(=O)CCc1ccc(C(=N)N)cc1)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 4/20 0.44
SMN1; SMN2 Q16637 2/20 0.40
MAPT P10636 2/20 0.40
TP53 P04637 1/20 0.40
GAA P10253 1/20 0.39
ADRB2 P07550 2/20 0.38
ADRB1 P08588 2/20 0.38
ADRB3 P13945 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
ALDH1A1 P00352 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
BRD4 O60885 1/20 0.37
CREBBP Q92793 1/20 0.37
AVPR2 P30518 1/20 0.37
OXTR P30559 1/20 0.37
AVPR1A P37288 1/20 0.37
ITGB3 P05106 1/20 0.37
ITGA2B P08514 1/20 0.37
OPRM1 P35372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6976365 0.88 NR3C1 (0.45) NR3C1TP53ALDH1A1LMNA
SCHEMBL6982524 0.86 NR3C1 (0.51) NR3C1SMN1; SMN2MAPTTP53GAA
Hydrochloric Acid SCHEMBL6987687 0.85 NR3C1 (0.50) NR3C1SMN1; SMN2MAPTTP53GAA
Hydrochloric Acid SCHEMBL6981120 0.82 NR3C1 (0.51) NR3C1SMN1; SMN2GAAMEN1KMT2A
SCHEMBL6978677 0.81 NR3C1 (0.40) NR3C1TP53ALDH1A1
Hydrochloric Acid SCHEMBL6985449 0.81 NR3C1 (0.40) NR3C1TP53ALDH1A1
Hydrochloric Acid SCHEMBL6985072 0.79 F2 (0.42) NR3C1SMN1; SMN2MAPTMEN1KMT2A
Hydrochloric Acid SCHEMBL6985423 0.79 NR3C1 (0.44) NR3C1SMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL6976671 0.79 F2 (0.41) NR3C1MAPTTP53GAAKMT2A
SCHEMBL6981742 0.78 NR3C1 (0.49) NR3C1SMN1; SMN2GAAADRB2ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991624-B1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2003-11-19 EP claimed
US-6300342-B1 FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION BOEHRINGER INGELHEIM PHARM KG (DE) 2001-10-09 US claimed
EP-0991624-A1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT Boehringer Ingelheim Pharma KG (DE) 2000-04-12 EP claimed
WO-1999000371-A1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-01-07 WO claimed
EP-0991624-B1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2003-11-19 EP disclosed
US-6300342-B1 FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION BOEHRINGER INGELHEIM PHARM KG (DE) 2001-10-09 US disclosed
EP-0991624-A1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT Boehringer Ingelheim Pharma KG (DE) 2000-04-12 EP disclosed
WO-1999000371-A1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-01-07 WO disclosed