Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | MASP2 | O00187 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6982510 | 0.91 | ADAM17 (0.39) | ADAM17CTSCMASP2HTR2AGRIK1 | |
| SCHEMBL6987279 | 0.85 | CTSC (0.32) | CTSC | |
| Hydrochloric Acid SCHEMBL7811423 | 0.85 | ADAM17 (0.39) | ADAM17CTSCMASP2HTR2AGRIK1 | |
| Hydrochloric Acid SCHEMBL6985991 | 0.85 | ADAM17 (0.39) | ADAM17CTSCMASP2HTR2AGRIK1 | |
| SCHEMBL6987148 | 0.80 | CTSC (0.35) | ADAM17CTSCMASP2HTR2AGRIK1 | |
| SCHEMBL6986618 | 0.78 | ADAM17 (0.37) | ADAM17CTSC | |
| SCHEMBL6941953 | 0.76 | ADAM17 (0.39) | ADAM17CTSCMASP2HTR2AGRIK1 | |
| Hydrochloric Acid SCHEMBL6983018 | 0.76 | CTSC (0.35) | ADAM17CTSCMASP2HTR2AGRIK1 | |
| SCHEMBL6984201 | 0.74 | ADAM17 (0.37) | ADAM17CTSC | |
| SCHEMBL6987205 | 0.74 | ADAM17 (0.37) | ADAM17CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |