Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27323821 | 0.78 | POLB (0.43) | PDE10AALDH1A1POLBMDM2GAA | |
| SCHEMBL7067937 | 0.77 | KDR (0.48) | PDE10AALDH1A1POLBMDM2GAA | |
| SCHEMBL27322492 | 0.74 | PDE10A (0.37) | PDE10AALDH1A1POLBMAPTNPSR1 | |
| SCHEMBL19924519 | 0.74 | PDE10A (0.44) | PDE10AALDH1A1POLBMDM2GAA | |
| SCHEMBL27310716 | 0.74 | NR3C2 (0.53) | PDE10AALDH1A1MDM2MAPK8MAPK9 | |
| SCHEMBL7369553 | 0.73 | HTT (0.47) | PDE10AALDH1A1POLBGAALMNA | |
| SCHEMBL28300954 | 0.72 | SMN1; SMN2 (0.50) | PDE10AALDH1A1POLBGAALMNA | |
| SCHEMBL27343295 | 0.71 | CYP2C9 (0.45) | PDE10APOLBMDM2LMNANPSR1 | |
| SCHEMBL6057416 | 0.71 | POLB (0.53) | PDE10AALDH1A1POLBMDM2GAA | |
| SCHEMBL17111160 | 0.71 | RAB9A (0.54) | ALDH1A1POLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |