Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27310716 | 0.80 | NR3C2 (0.53) | PDE10AMAPK8MAPK9MAPK10MDM2 | |
| SCHEMBL28300954 | 0.79 | SMN1; SMN2 (0.50) | PDE10AMAPK8MAPK9MAPK10NR3C2 | |
| SCHEMBL27353158 | 0.77 | MDM2 (0.50) | PDE10AMAPK8MAPK9MAPK10MDM2 | |
| SCHEMBL6981888 | 0.77 | PDE10A (0.46) | PDE10AMAPK8MAPK9MAPK10MDM2 | |
| SCHEMBL27353154 | 0.74 | POLB (0.53) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL1155787 | 0.74 | MDM2 (0.55) | PDE10AMAPK8MAPK9MAPK10MDM2 | |
| SCHEMBL17086633 | 0.73 | MDM2 (0.52) | MAPK8MAPK9MAPK10MDM2NR3C2 | |
| SCHEMBL1422182 | 0.72 | HSD17B1 (0.67) | KDRMEN1KMT2AOXTRHSD17B1 | |
| SCHEMBL27730925 | 0.72 | ALDH1A1 (0.55) | KDRMEN1KMT2AMAPK8MAPK9 | |
| SCHEMBL27519346 | 0.72 | NR3C2 (0.47) | PDE10AMAPK8MAPK9MAPK10MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003045950-A1 | PYRAZOLOPYRIDINE DERIVTIVES AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |
| WO-2002100864-A1 | PYRAZOLOPYRAZINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-19 | — | — | WO | disclosed |