Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 5/20 | 0.44 |
| ▸ | PLAU | P00749 | 4/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14381015 | 0.79 | F12 (0.44) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL1834564 | 0.77 | PLAU (0.59) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL6776349 | 0.76 | ROCK1 (0.46) | PLAUNCF1PLATF10ROCK1 | |
| SCHEMBL30676373 | 0.76 | PLAU (0.44) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL6769265 | 0.76 | PLAU (0.43) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL6978513 | 0.76 | PLAU (0.63) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL6769241 | 0.76 | ROCK1 (0.45) | PLAUPLATROCK1 | |
| SCHEMBL6435678 | 0.75 | CA1 (0.44) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL14404768 | 0.74 | TYMS (0.50) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL7120850 | 0.73 | ROCK1 (0.45) | F12PLAUNCF1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012166-B1 | 1-AMINO-7-ISOQUINOLINE DERIVATIVES AS SERINE PROTEASE INHIBITORS | TULARIK LTD (GB) | 2003-10-29 | — | — | EP | claimed |