Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 13/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8142191 | 0.90 | DRD2 (0.46) | HTR1DDRD2HTR1ASLC6A4HTR7 | |
| SCHEMBL6984827 | 0.88 | HTR1D (0.43) | HTR1DDRD2HTR1ASLC6A4HTR7 | |
| SCHEMBL7948126 | 0.88 | SLC6A4 (0.47) | HTR1DDRD2HTR1ASLC6A4HTR7 | |
| Hydrochloric Acid SCHEMBL8142767 | 0.80 | DRD2 (0.47) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL8146214 | 0.78 | DRD2 (0.51) | HTR1DDRD2HTR1ASLC6A4HTR7 | |
| Hydrochloric Acid SCHEMBL8146317 | 0.77 | DRD2 (0.49) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL8148639 | 0.77 | DRD2 (0.54) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL8142741 | 0.76 | SLC6A4 (0.51) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL6984803 | 0.75 | TDO2 (0.49) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL8147241 | 0.74 | DRD2 (0.46) | HTR1DDRD2HTR1ASLC6A4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |