Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985482 | 0.92 | HTR6 (0.45) | HTR6TSPO | |
| SCHEMBL6983411 | 0.92 | HTR6 (0.45) | HTR6TSPO | |
| SCHEMBL6697892 | 0.89 | HTR6 (0.43) | HTR6TSPO | |
| SCHEMBL6697710 | 0.85 | HTR6 (0.47) | HTR6TSPO | |
| SCHEMBL6976610 | 0.82 | HTR6 (0.48) | HTR6KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4263164 | 0.81 | HTR6 (0.55) | HTR6ALDH1A1TSPO | |
| SCHEMBL6983468 | 0.80 | HTR6 (0.51) | HTR6TSPO | |
| SCHEMBL6694888 | 0.80 | HTR6 (0.51) | HTR6TSPO | |
| SCHEMBL11819992 | 0.78 | HTR6 (0.53) | HTR6KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6983058 | 0.77 | HTR6 (0.46) | HTR6KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839806-B1 | Substituted tricyclics | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-1998018464-A1 | SUBSTITUTED TRICYCLICS | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |
| EP-0839806-A1 | Substituted tricyclics | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |