Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698959 | 0.94 | KCNA5 (0.71) | KCNA5KCNH2ALDH1A1TP53GAA | |
| SCHEMBL10494268 | 0.84 | KCNA5 (0.65) | KCNA5KCNH2ALDH1A1TP53GAA | |
| SCHEMBL10375360 | 0.83 | KCNA5 (0.58) | KCNA5KCNH2ALDH1A1TP53GAA | |
| SCHEMBL13021000 | 0.83 | KCNA5 (0.71) | KCNA5KCNH2ALDH1A1MCL1PTGDR2 | |
| SCHEMBL9814888 | 0.76 | KCNA5 (0.56) | KCNA5KCNH2ALDH1A1MCL1TBXAS1 | |
| SCHEMBL9363306 | 0.74 | KCNA5 (0.65) | KCNA5KCNH2ALDH1A1TP53MCL1 | |
| SCHEMBL9362957 | 0.74 | KCNA5 (0.54) | KCNA5KCNH2ALDH1A1MCL1TBXAS1 | |
| SCHEMBL4527403 | 0.74 | KMT2A (0.48) | KCNA5KCNH2ALDH1A1MCL1KMT2A | |
| SCHEMBL10374845 | 0.73 | LMNA (0.52) | KCNA5KCNH2ALDH1A1MCL1TBXAS1 | |
| SCHEMBL10374719 | 0.73 | KCNA5 (0.58) | KCNA5KCNH2ALDH1A1TP53MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423190-A1 | Compounds Exhibiting PGD 2 Receptor Antagonism | Shionogi&Co., Ltd. (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-20090258922-A1 | COMPOUND EXHIBITING PGD2 RECEPTOR ANTAGONIST | SHIONOGI & CO., LTD. | 2009-10-15 | — | — | US | disclosed |
| US-7534897-B2 | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism | SHIONOGI & CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| US-20050171143-A1 | Compound exhibiting pgd 2 receptor antagonism | SHIONOGI & CO., LTD. (JP) | 2005-08-04 | — | — | US | disclosed |
| EP-1505061-A1 | COMPOUND EXHIBITING PGD 2 RECEPTOR ANTAGONISM | SHIONOGI & CO., LTD. (JP) | 2005-02-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258922-A1 | COMPOUND EXHIBITING PGD2 RECEPTOR ANTAGONIST | CYSLTR2, CYSLTR1, HRH2 | KCNA5 2720/4885KCNH2 2050/4885ALDH1A1 1713/4885 |
| US-20050171143-A1 | Compound exhibiting pgd 2 receptor antagonism | CYSLTR2, CYSLTR1, HRH2 | KCNA5 2974/4885KCNH2 2475/4885ALDH1A1 1732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.