Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410255 | 0.83 | CA2 (0.40) | CYP2D6TDP1GAAPTPRCCA2 | |
| Hydrochloric Acid SCHEMBL31480795 | 0.81 | CA2 (0.39) | CYP2D6TDP1GAAPTPRCCA2 | |
| Hydrochloric Acid SCHEMBL219630 | 0.81 | CA2 (0.39) | CYP2D6TDP1GAAPTPRCCA2 | |
| SCHEMBL3297 | 0.81 | CYP3A4 (0.44) | CYP3A4CYP2D6CYP1A2CYP2C9NFKB1 | |
| SCHEMBL206710 | 0.81 | CYP3A4 (0.44) | CYP3A4CYP2D6CYP1A2CYP2C9NFKB1 | |
| SCHEMBL320243 | 0.81 | CYP3A4 (0.44) | CYP3A4CYP2D6CYP1A2CYP2C9NFKB1 | |
| Hydrochloric Acid SCHEMBL214837 | 0.79 | LMNA (0.46) | CYP3A4CYP2D6CYP1A2CYP2C9NFKB1 | |
| Hydrochloric Acid SCHEMBL975844 | 0.79 | LMNA (0.46) | CYP3A4CYP2D6CYP1A2CYP2C9NFKB1 | |
| Hydrochloric Acid SCHEMBL14744098 | 0.79 | LMNA (0.46) | CYP3A4CYP2D6CYP1A2CYP2C9NFKB1 | |
| Hydrochloric Acid SCHEMBL320242 | 0.79 | LMNA (0.46) | CYP3A4CYP2D6CYP1A2CYP2C9NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244446-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1244446-A1 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001039773-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-07 | — | — | WO | disclosed |