Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 5/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 3/20 | 0.39 |
| ▸ | CHRND | Q07001 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970913 | 0.88 | OPRM1 (0.45) | OPRM1SLC6A4OPRD1OPRK1SLC22A1 | |
| SCHEMBL6978140 | 0.87 | OPRM1 (0.49) | OPRM1SLC6A4OPRD1OPRK1SLC22A1 | |
| SCHEMBL6979503 | 0.87 | OPRM1 (0.48) | OPRM1SLC6A4SLC6A2SLC6A3OPRD1 | |
| SCHEMBL20592807 | 0.86 | SMN1; SMN2 (0.44) | OPRM1SLC6A4CHRNA1CHRNB1CHRNB2 | |
| SCHEMBL6979724 | 0.83 | OPRM1 (0.45) | OPRM1SLC6A4OPRD1OPRK1SLC22A1 | |
| SCHEMBL6979573 | 0.82 | OPRM1 (0.49) | OPRM1OPRK1SMN1; SMN2MAPTGAA | |
| SCHEMBL6971603 | 0.82 | CHRNA1 (0.40) | SLC6A4CHRNA1CHRNB1CHRNB2SLC6A2 | |
| SCHEMBL6974990 | 0.81 | OPRM1 (0.46) | OPRM1SLC6A4OPRD1OPRK1SLC22A1 | |
| SCHEMBL6981106 | 0.80 | APP (0.43) | OPRM1SLC6A4OPRD1OPRK1SLC22A1 | |
| SCHEMBL7145811 | 0.79 | APP (0.38) | OPRM1SLC6A4OPRD1OPRK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |