Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 7/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 7/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.40 |
| ▸ | CHRNG | P07510 | 5/20 | 0.40 |
| ▸ | CHRND | Q07001 | 5/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967893 | 0.85 | CNR1 (0.40) | HSD11B1KMT2AMAPTALDH1A1 | |
| SCHEMBL20592907 | 0.84 | HSD11B1 (0.43) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL6981777 | 0.84 | AKR1C1 (0.41) | MEN1KMT2ALMNAHTTALDH1A1 | |
| SCHEMBL6973280 | 0.84 | SLC6A2 (0.37) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL6982866 | 0.82 | OPRM1 (0.41) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL377756 | 0.80 | MAPK1 (0.40) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL6982594 | 0.76 | HSD11B1 (0.39) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL6978477 | 0.76 | LMNA (0.39) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL6984599 | 0.74 | RXRA (0.53) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL7137847 | 0.74 | LMNA (0.42) | HCAR3HCAR2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |