SCHEMBL6982873

SCHEMBL6982873

c1ccc(/C(=N\Nc2nc3ccccc3s2)C2CCCCC2)nc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.61
HSP90AA1 P07900 3/20 0.61
CYP1A2 P05177 2/20 0.61
CYP3A4 P08684 2/20 0.61
HIF1A Q16665 1/20 0.61
RAB9A P51151 10/20 0.48
KMT2A Q03164 8/20 0.48
NPC1 O15118 8/20 0.48
MAPT P10636 8/20 0.48
MEN1 O00255 7/20 0.48
SMN1; SMN2 Q16637 7/20 0.48
GAA P10253 6/20 0.48
NPSR1 Q6W5P4 3/20 0.48
KDM4E B2RXH2 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
POLB P06746 1/20 0.48
PAX8 Q06710 1/20 0.48
NFKB1 P19838 2/20 0.46
NFKB2 Q00653 2/20 0.46
RELA Q04206 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5928815 1.00 ALDH1A1 (0.61) ALDH1A1HSP90AA1CYP1A2CYP3A4HIF1A
SCHEMBL20101082 0.80 HSP90AA1 (0.85) ALDH1A1HSP90AA1CYP1A2CYP3A4HIF1A
SCHEMBL17985747 0.78 HSP90AA1 (0.76) ALDH1A1HSP90AA1CYP1A2CYP3A4HIF1A
SCHEMBL15427107 0.76 HSP90AA1 (1.00) ALDH1A1HSP90AA1CYP1A2CYP3A4HIF1A
SCHEMBL19449283 0.75 ALDH1A1 (0.65) ALDH1A1HSP90AA1CYP1A2CYP3A4HIF1A
SCHEMBL17985744 0.75 ALDH1A1 (0.65) ALDH1A1HSP90AA1CYP1A2CYP3A4HIF1A
SCHEMBL17963015 0.75 HSP90AA1 (0.65) ALDH1A1HSP90AA1CYP1A2CYP3A4HIF1A
SCHEMBL4909101 0.71 NPC1 (0.70) ALDH1A1CYP1A2RAB9AKMT2ANPC1
SCHEMBL17987892 0.71 HSP90AA1 (0.59) ALDH1A1HSP90AA1CYP1A2CYP3A4HIF1A
SCHEMBL6229312 0.70 NPC1 (0.76) ALDH1A1RAB9AKMT2ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1286987-A1 HETEROCYCLIC HYDRAZONES FOR USE AS ANTI-CANCER AGENTS Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung (AT) 2003-03-05 EP disclosed
WO-2001094340-A1 HETEROCYCLIC HYDRAZONES FOR USE AS ANTI-CANCER AGENTS INNOVATIONSAGENTUR GESELLSCHAFT M.B.H. (AT) 2001-12-13 WO disclosed