SCHEMBL20101082

SCHEMBL20101082

c1ccc(C(=NNc2nc3ccccc3s2)c2ccccn2)nc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.85
ALDH1A1 P00352 3/20 0.85
CYP1A2 P05177 1/20 0.85
CYP3A4 P08684 1/20 0.85
HIF1A Q16665 1/20 0.85
MAPT P10636 11/20 0.56
KMT2A Q03164 8/20 0.56
TDP1 Q9NUW8 3/20 0.56
NPSR1 Q6W5P4 2/20 0.56
POLB P06746 2/20 0.56
KDM4E B2RXH2 1/20 0.56
PAX8 Q06710 1/20 0.56
RAB9A P51151 9/20 0.51
GAA P10253 8/20 0.51
NPC1 O15118 7/20 0.51
MEN1 O00255 7/20 0.51
HPGD P15428 2/20 0.51
ALOX12 P18054 2/20 0.51
LMNA P02545 2/20 0.51
SMN1; SMN2 Q16637 8/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15427107 0.92 HSP90AA1 (1.00) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL17985747 0.86 HSP90AA1 (0.76) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL17963015 0.83 HSP90AA1 (0.65) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL19449283 0.83 ALDH1A1 (0.65) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL17985744 0.83 ALDH1A1 (0.65) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL5928815 0.80 ALDH1A1 (0.61) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL6982873 0.80 ALDH1A1 (0.61) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL17987892 0.79 HSP90AA1 (0.59) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL20101036 0.79 HSP90AA1 (0.76) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL6229312 0.77 NPC1 (0.76) ALDH1A1MAPTKMT2ATDP1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018081612-A1 COMPOUNDS AND METHODS FOR TREATING CANCER ACTAVALON, INC. (US) 2018-05-03 WO disclosed