SCHEMBL6982876

SCHEMBL6982876

O=C1CCn2c3ccc(Cl)cc3c3cccc1c32

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.36
LMNA P02545 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
KDM4E B2RXH2 3/20 0.36
MAPK1 P28482 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TSHR P16473 1/20 0.36
ALOX12 P18054 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KMT2A Q03164 3/20 0.36
PARP1 P09874 1/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP1B1 Q16678 1/20 0.36
MEN1 O00255 2/20 0.35
ALOX5 P09917 2/20 0.35
MTNR1A P48039 1/20 0.35
MTNR1B P49286 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6982156 0.86 VHL (0.39) MAPTLMNAKDM4EMAPK1ALDH1A1
SCHEMBL6977937 0.83 MEN1 (0.40) MAPTLMNASMN1; SMN2KDM4EMAPK1
SCHEMBL6981939 0.82 PIM1 (0.42) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL7668704 0.81 MAPT (0.34) MAPTLMNASMN1; SMN2KDM4EMAPK1
SCHEMBL6971871 0.79 MAPT (0.44) MAPTLMNASMN1; SMN2KDM4EMAPK1
SCHEMBL6981782 0.78 HTR2A (0.39) MAPTLMNAKDM4EMAPK1ALDH1A1
SCHEMBL7670693 0.77 SMARCA4 (0.41) KDM4EALDH1A1HPGDHSD17B10ATM
SCHEMBL7663863 0.76 MAPT (0.34) MAPTLMNAKDM4EMAPK1ALDH1A1
SCHEMBL6972543 0.75 DNMT1 (0.35) MAPTLMNASMN1; SMN2KDM4EALDH1A1
SCHEMBL6983511 0.72 TUBB4A (0.42) MAPTKDM4EMAPK1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6197768-B1 THERAPY, PREVENTION ISCHEMIC HEART DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-0992240-A1 THERAPEUTIC AGENT FOR ERECTION FAILURE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-04-12 EP disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed