Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA4 | P51532 | 4/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981939 | 0.90 | PIM1 (0.42) | SMARCA4PBRM1KDM4EHPGDHSD17B10 | |
| SCHEMBL6982876 | 0.77 | MAPT (0.36) | KDM4EHPGDHSD17B10ALDH1A1ATM | |
| SCHEMBL6977937 | 0.77 | MEN1 (0.40) | KDM4EHPGDHSD17B10PABPC1ALDH1A1 | |
| SCHEMBL13703783 | 0.75 | KDM4E (0.39) | SMARCA4KDM4EHPGDALDH1A1P2RX4 | |
| SCHEMBL6982969 | 0.75 | KMT2A (0.46) | KDM4EHSD17B10PABPC1ALDH1A1 | |
| SCHEMBL5273693 | 0.74 | PARP1 (0.44) | KDM4EHPGDHSD17B10DHFR | |
| SCHEMBL13851541 | 0.73 | MEN1 (0.61) | KDM4EHPGDHSD17B10PABPC1ALDH1A1 | |
| SCHEMBL13703630 | 0.73 | MAPT (0.49) | KDM4EHPGDALDH1A1P2RX4ATM | |
| SCHEMBL6971871 | 0.73 | MAPT (0.44) | KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL7005451 | 0.72 | HTR3A (0.36) | KDM4EHPGDHSD17B10PABPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |