Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | CCR3 | P51677 | 9/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | ACACA | Q13085 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10144835 | 0.86 | KDM4E (0.76) | KDM4EPKMNAMPTACACBACACA | |
| SCHEMBL28191245 | 0.81 | MET (0.53) | KDM4EPKMCCR3GPR119POLB | |
| SCHEMBL6980865 | 0.81 | KDM4E (0.61) | KDM4EPKMHTR3AGPR119POLB | |
| SCHEMBL6979528 | 0.80 | KDM4E (0.76) | KDM4EPKMNAMPTRORCGPR119 | |
| SCHEMBL26131403 | 0.79 | KDM4E (1.00) | KDM4EPKMNAMPTACACBACACA | |
| SCHEMBL5424115 | 0.79 | KDM4E (0.62) | KDM4EPKMNAMPTRORCGPR119 | |
| SCHEMBL6984094 | 0.79 | KDM4E (0.71) | KDM4EPKMNAMPTRORCGPR119 | |
| SCHEMBL7467887 | 0.79 | KDM4E (0.64) | KDM4EPKMGPR119POLB | |
| SCHEMBL13947430 | 0.78 | KDM4E (0.80) | KDM4EPKMNAMPTRORCGPR119 | |
| SCHEMBL15661860 | 0.78 | KDM4E (0.80) | KDM4EPKMNAMPTRORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | disclosed |