SCHEMBL6964689

SCHEMBL6964689

Cc1cc(CC[O])c2ccccc2n1

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.56
NCF1 P14598 3/20 0.53
SMN1; SMN2 Q16637 4/20 0.48
HTT P42858 3/20 0.48
KDM4E B2RXH2 2/20 0.48
RAB9A P51151 2/20 0.48
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
ALDH1A1 P00352 2/20 0.46
GALR3 O60755 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
CYP2C19 P33261 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3964916 0.85 CYP1A2 (0.60) CYP1A2NCF1SMN1; SMN2HTTKDM4E
SCHEMBL18535317 0.84 CYP1A2 (0.58) CYP1A2NCF1SMN1; SMN2HTTKDM4E
SCHEMBL8232676 0.83 CYP1A2 (0.62) CYP1A2NCF1SMN1; SMN2HTTKDM4E
SCHEMBL6788358 0.82 CYP2C19 (0.56) CYP1A2NCF1SMN1; SMN2HTTKDM4E
SCHEMBL28728112 0.82 CYP1A2 (0.56) CYP1A2NCF1SMN1; SMN2HTTKDM4E
SCHEMBL6783499 0.82 NCF1 (0.58) CYP1A2NCF1SMN1; SMN2HTTKDM4E
SCHEMBL1366357 0.79 CYP1A2 (0.62) CYP1A2NCF1SMN1; SMN2HTTKDM4E
SCHEMBL6789734 0.79 CYP1A2 (0.53) CYP1A2NCF1SMN1; SMN2HTTKDM4E
SCHEMBL6788451 0.79 NCF1 (0.60) CYP1A2NCF1HTTRAB9AKMT2A
SCHEMBL6790022 0.79 NCF1 (0.60) CYP1A2NCF1SMN1; SMN2HTTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6642255-B2 Substituted carbocyclic or heterocyclic hydroxamic acid derivatives, e.g., (3R,4S)-N-hydroxy-1-methyl-3-(((4-((2-methyl-4 -quinolinyl)methoxylphenyl)sulfonyl)methyl)-4-piperidinecarboxamide BRISTOL-MYERS SQUIBB PHARMA COMPANY 2003-11-04 US disclosed
EP-1355648-A2 1,2-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLORPROTEASES AND TNF-$g(a) Bristol-Myers Squibb Pharma Company (US) 2003-10-29 EP disclosed
US-6455522-B1 ANTIINFLAMMATORY AGENTS; AGGRECANASE AND TUMOR NECROSIS FACTOR INHIBITORS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-09-24 US disclosed
WO-2002055491-A2 1,2-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLORPROTEASES AND TNF-$g(a) BRISTOL MYERS SQUIBB COMPANY P (US) 2002-07-18 WO disclosed