Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.57 |
| ▸ | DRD3 | P35462 | 19/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976536 | 0.96 | DRD3 (0.52) | DRD2DRD3PRMT5WDR77 | |
| SCHEMBL6984464 | 0.84 | DRD3 (0.52) | DRD2DRD3 | |
| SCHEMBL6981220 | 0.82 | DRD3 (0.81) | DRD2DRD3 | |
| SCHEMBL7843315 | 0.82 | DRD3 (0.63) | DRD2DRD3PRMT5WDR77 | |
| SCHEMBL7843695 | 0.82 | DRD3 (0.61) | DRD2DRD3 | |
| SCHEMBL7854476 | 0.81 | DRD3 (0.58) | DRD2DRD3 | |
| SCHEMBL7856243 | 0.81 | DRD2 (0.53) | DRD2DRD3 | |
| SCHEMBL8133764 | 0.80 | DRD2 (0.56) | DRD2DRD3 | |
| SCHEMBL8132675 | 0.80 | DRD3 (0.62) | DRD2DRD3 | |
| SCHEMBL8059024 | 0.80 | DRD2 (0.56) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0917530-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-02-19 | — | — | EP | disclosed |
| US-6046210-A | ANTIPSYCHOTIC AGENTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-04-04 | — | — | US | disclosed |
| EP-0981516-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D?3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-01 | — | — | EP | disclosed |
| EP-0917530-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1999-05-26 | — | — | EP | disclosed |
| WO-1998049145-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-05 | — | — | WO | disclosed |
| WO-1997043262-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-11-20 | — | — | WO | disclosed |