Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 17/20 | 0.58 |
| ▸ | DRD2 | P14416 | 17/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 4/20 | 0.56 |
| ▸ | HTR1B | P28222 | 4/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962824 | 0.96 | DRD3 (0.58) | DRD3DRD2DRD4OPRM1HTR1D | |
| SCHEMBL6984464 | 0.84 | DRD3 (0.52) | DRD3DRD2DRD4 | |
| SCHEMBL7843315 | 0.82 | DRD3 (0.63) | DRD3DRD2HTR1AHTR2ASLC6A4 | |
| SCHEMBL7843695 | 0.82 | DRD3 (0.61) | DRD3DRD2DRD4 | |
| SCHEMBL6983214 | 0.81 | DRD2 (0.57) | DRD3DRD2 | |
| SCHEMBL7976693 | 0.80 | DRD3 (0.51) | DRD3DRD2DRD4TMEM97 | |
| SCHEMBL7979139 | 0.80 | DRD3 (0.49) | DRD3DRD2DRD4TMEM97 | |
| SCHEMBL6979746 | 0.79 | DRD3 (0.74) | DRD3DRD2DRD4OPRM1HTR1D | |
| SCHEMBL7856243 | 0.79 | DRD2 (0.53) | DRD3DRD2HTR7 | |
| SCHEMBL7976536 | 0.77 | DRD3 (0.52) | DRD3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922035-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | disclosed |
| US-6143762-A | DRUGS AS DOPAMINE ANTAGONIST PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM, PLC (GB) | 2000-11-07 | — | — | US | disclosed |
| EP-0981516-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D?3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-01 | — | — | EP | disclosed |
| WO-1998049145-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-05 | — | — | WO | disclosed |