SCHEMBL6983331

SCHEMBL6983331

O=c1c2ccccc2n(CCCc2cnc[nH]2)c(=O)n1-c1cccc(Br)c1

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 11/20 0.47
SSTR3 P32745 10/20 0.47
SSTR1 P30872 8/20 0.47
PGR P06401 3/20 0.44
SSTR2 P30874 4/20 0.43
FNTA P49354 1/20 0.41
FNTB P49356 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6981003 0.83 SSTR4 (0.48) SSTR4SSTR3SSTR1PGRSSTR2
SCHEMBL6978458 0.81 PGR (0.47) PGR
SCHEMBL6976722 0.79 PGR (0.44) SSTR4SSTR3SSTR1PGR
SCHEMBL6972587 0.77 PGR (0.48) PGRFNTAFNTB
SCHEMBL6981373 0.77 SSTR4 (0.50) SSTR4SSTR3SSTR1SSTR2FNTA
SCHEMBL6979415 0.77 TSHR (0.49) PGRFNTAFNTB
SCHEMBL6982647 0.75 CYP11B1 (0.43) PGRFNTAFNTB
SCHEMBL6982742 0.75 PGR (0.41) PGRFNTAFNTB
SCHEMBL6981944 0.73 FNTA (0.48) FNTAFNTB
SCHEMBL6980086 0.73 TP53 (0.47) PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030199530-A1 New compounds derived from quinazoline LES LABORATORIES SERVIER (FR) 2003-10-23 US disclosed
EP-1346992-A1 Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them Les Laboratoires Servier (FR) 2003-09-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030199530-A1 New compounds derived from quinazoline NQO2, XDH, DRD1 SSTR4 4554/4885SSTR3 4431/4885SSTR1 4014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.