Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29161611 | 0.79 | ALDH1A1 (0.56) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL21809815 | 0.78 | PDE3B (0.47) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL17810128 | 0.77 | PDE3B (0.56) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL22308111 | 0.76 | PDE3B (0.58) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL698276 | 0.76 | MAPK1 (0.56) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL22308112 | 0.75 | PDE3B (0.60) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL16140693 | 0.75 | PDE3B (0.86) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL2986415 | 0.74 | NPC1 (0.38) | PDE3BPDE3AALDH1A1ALOX15TSHR | |
| SCHEMBL711780 | 0.74 | ALDH1A1 (0.65) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL17814913 | 0.74 | PDE3B (0.54) | PDE3BPDE3AMAPK1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421612-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | Novartis AG (CH) | 2012-02-29 | — | — | EP | disclosed |