Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15157628 | 0.96 | PDE3B (0.53) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL17810128 | 0.85 | PDE3B (0.56) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL22308111 | 0.84 | PDE3B (0.58) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL22308112 | 0.83 | PDE3B (0.60) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL15157734 | 0.82 | KCNK3 (0.46) | KCNK3 | |
| SCHEMBL15165969 | 0.82 | PDE3B (0.55) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL17591385 | 0.82 | PDE3B (0.53) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL15157715 | 0.81 | KCNK3 (0.37) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL21810002 | 0.81 | PDE3B (0.55) | PDE3BPDE3AMAPK1GAAALDH1A1 | |
| SCHEMBL15166121 | 0.79 | PDE3B (0.36) | PDE3BPDE3AMAPK1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884860-B2 | Fused pyrroledicarboxamides and their use as pharmaceuticals | SANOFI (FR) | 2018-02-06 | — | — | US | disclosed |
| US-20160159793-A1 | Fused Pyrroledicarboxamides and Their Use as Pharmaceuticals | SANOFI (FR) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159793-A1 | Fused Pyrroledicarboxamides and Their Use as Pharmaceuticals | KCNA1, KCNE1, KCNH1 | PDE3B 4444/4885PDE3A 4051/4885MAPK1 1727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.