Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 3/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | THPO | P40225 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978977 | 0.98 | SCN1A (0.50) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 | |
| SCHEMBL21861456 | 0.98 | SCN1A (0.50) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 | |
| SCHEMBL6981112 | 0.98 | SCN1A (0.50) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 | |
| SCHEMBL10356352 | 0.94 | SCN1A (0.53) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 | |
| SCHEMBL4670218 | 0.89 | SCN1A (0.61) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 | |
| SCHEMBL2017633 | 0.85 | CHRM2 (0.57) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 | |
| SCHEMBL4669231 | 0.85 | SLC6A2 (0.61) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 | |
| SCHEMBL595711 | 0.81 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3LMNAKCNH2 | |
| SCHEMBL4667564 | 0.80 | SCN1A (0.65) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 | |
| SCHEMBL14380431 | 0.80 | KCNH2 (0.56) | SCN1ASCN2ASCN3ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0923575-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008842-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-05 | — | — | WO | disclosed |