Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843143 | 0.94 | SIGMAR1 (0.55) | SIGMAR1CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL5842304 | 0.88 | SIGMAR1 (0.54) | SIGMAR1CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL5840962 | 0.82 | SIGMAR1 (0.43) | SIGMAR1CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL17598264 | 0.79 | SMN1; SMN2 (0.61) | CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL5841480 | 0.79 | SIGMAR1 (0.49) | SIGMAR1CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL5841337 | 0.77 | SIGMAR1 (0.49) | SIGMAR1CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL9151071 | 0.74 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7 | |
| SCHEMBL9149589 | 0.74 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7 | |
| SCHEMBL9152244 | 0.74 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7 | |
| SCHEMBL11851576 | 0.74 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |