Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840975 | 0.90 | SIGMAR1 (0.47) | SIGMAR1CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL6983501 | 0.82 | SIGMAR1 (0.52) | SIGMAR1CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL27065452 | 0.78 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1USP2ALOX15TDP1 | |
| SCHEMBL5175373 | 0.78 | MAPK1 (0.47) | CHRM1SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL24001256 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1POLBALOX15TDP1 | |
| SCHEMBL24001095 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1POLBALOX15TDP1 | |
| SCHEMBL24757426 | 0.77 | CYP1A2 (0.48) | SMN1; SMN2ALDH1A1POLBALOX15TDP1 | |
| SCHEMBL5843143 | 0.76 | SIGMAR1 (0.55) | SIGMAR1CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL24001257 | 0.76 | BCHE (0.48) | SMN1; SMN2ALDH1A1USP2ALOX15TDP1 | |
| SCHEMBL28920842 | 0.76 | BCHE (0.48) | SMN1; SMN2ALDH1A1USP2ALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992085-B2 | Octahydro-2H-pyrido[1,2-a]pyrazine compounds | LES LABORATORIES SERVIER (FR) | 2006-01-31 | — | — | US | disclosed |
| US-20030195216-A1 | Octahydro-2H-pyrido[1,2-a] pyrazine compounds | LES LABORATOIRES SERVIER (FR) | 2003-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195216-A1 | Octahydro-2H-pyrido[1,2-a] pyrazine compounds | CYP2W1, OXER1, IL1R1 | SIGMAR1 47/4885CHRM5 219/4885CHRM1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.