SCHEMBL6983830

SCHEMBL6983830

CC(NC(=O)N1CCN(C(=O)SC(=O)c2ccccc2)CC1)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GPR139 Q6DWJ6 2/20 0.50
CACNA2D1 P54289 2/20 0.48
CACNA1B Q00975 2/20 0.48
CACNB1 Q02641 2/20 0.48
CACNA1C Q13936 1/20 0.48
P2RY12 Q9H244 1/20 0.45
ALDH1A1 P00352 2/20 0.44
NPC1 O15118 1/20 0.44
ATM Q13315 1/20 0.43
GRM5 P41594 1/20 0.43
FBP1 P09467 1/20 0.43
HTT P42858 1/20 0.42
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42
HPGD P15428 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MAOB P27338 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6988112 0.99 GPR139 (0.49) GPR139CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL6987678 0.88 CYP3A4 (0.47) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
Hydrochloric Acid SCHEMBL4681386 0.87 CYP3A4 (0.46) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL28232257 0.79 NPC1 (0.57) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL4575059 0.79 NPC1 (0.57) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
Hydrochloric Acid SCHEMBL6988792 0.78 KMT2A (0.58) ALDH1A1NPC1
SCHEMBL6984610 0.77 NPC1 (0.55) P2RY12NPC1LMNA
SCHEMBL4677423 0.77 KDM4E (0.56) ALDH1A1HTTKDM4EHPGD
Hydrochloric Acid SCHEMBL6990408 0.76 KMT2A (0.51) ALDH1A1HTTKDM4E
Hydrochloric Acid SCHEMBL6993204 0.76 POLB (0.56) ALDH1A1HTTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1343775-A2 PIPERAZINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2003-09-17 EP disclosed
WO-2002048124-A2 PIPERAZINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-06-20 WO disclosed