Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983833 | 1.00 | JAK3 (0.47) | JAK3RXFP1FLT3RAF1PDPK1 | |
| SCHEMBL6982836 | 0.93 | JAK3 (0.44) | JAK3RXFP1FLT3PDPK1AKT1 | |
| SCHEMBL7985455 | 0.93 | JAK3 (0.44) | JAK3RXFP1FLT3PDPK1AKT1 | |
| SCHEMBL6984575 | 0.90 | JAK3 (0.42) | JAK3RXFP1PDPK1PAK4CYP3A4 | |
| SCHEMBL6984569 | 0.90 | JAK3 (0.42) | JAK3RXFP1PDPK1PAK4CYP3A4 | |
| SCHEMBL7236082 | 0.90 | JAK3 (0.48) | JAK3RXFP1FLT3PDPK1AKT1 | |
| SCHEMBL7236087 | 0.90 | JAK3 (0.48) | JAK3RXFP1FLT3PDPK1AKT1 | |
| SCHEMBL6979863 | 0.89 | ACHE (0.44) | JAK3 | |
| SCHEMBL6979865 | 0.89 | ACHE (0.44) | JAK3 | |
| SCHEMBL7237420 | 0.88 | PDPK1 (0.43) | JAK3RXFP1FLT3PDPK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |