Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984575 | 1.00 | JAK3 (0.42) | JAK3ROCK2SLC2A1CYP3A4HDAC3 | |
| SCHEMBL6979863 | 0.93 | ACHE (0.44) | JAK3HDAC1BCHEACHE | |
| SCHEMBL6979865 | 0.93 | ACHE (0.44) | JAK3HDAC1BCHEACHE | |
| SCHEMBL8188416 | 0.93 | MEN1 (0.46) | ROCK2HDAC1MEN1KMT2A | |
| SCHEMBL8188423 | 0.93 | MEN1 (0.46) | ROCK2HDAC1MEN1KMT2A | |
| SCHEMBL7984825 | 0.92 | ROCK2 (0.41) | JAK3ROCK2SLC2A1CYP3A4HDAC3 | |
| SCHEMBL4611892 | 0.91 | ROCK2 (0.40) | JAK3ROCK2SLC2A1PDPK1MEN1 | |
| SCHEMBL14587215 | 0.91 | ROCK2 (0.40) | JAK3ROCK2SLC2A1PDPK1MEN1 | |
| SCHEMBL4611898 | 0.91 | ROCK2 (0.40) | JAK3ROCK2SLC2A1PDPK1MEN1 | |
| SCHEMBL6971260 | 0.91 | JAK3 (0.41) | JAK3ROCK2PDPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |