Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987450 | 1.00 | CPB2 (0.35) | CPB2GSRCA14HDAC1HDAC2 | |
| SCHEMBL6653557 | 0.88 | CPB2 (0.36) | CPB2GSRHDAC1HDAC2HDAC6 | |
| SCHEMBL17369161 | 0.86 | CPB2 (0.39) | CPB2GSRHDAC1HDAC2HDAC6 | |
| SCHEMBL7416589 | 0.86 | CPB2 (0.42) | CPB2GSRHDAC1HDAC2HDAC6 | |
| SCHEMBL1039473 | 0.86 | CPB2 (0.42) | CPB2GSRHDAC1HDAC2HDAC6 | |
| SCHEMBL2211497 | 0.86 | CPB2 (0.42) | CPB2GSRHDAC1HDAC2HDAC6 | |
| Ethylenediamine SCHEMBL17669759 | 0.85 | CPB2 (0.41) | CPB2GSRHDAC1HDAC2HDAC6 | |
| Ethylenediamine SCHEMBL17669758 | 0.85 | CPB2 (0.41) | CPB2GSRHDAC1HDAC2HDAC6 | |
| SCHEMBL1053261 | 0.84 | CPB2 (0.34) | CPB2GSRHDAC1HDAC2HDAC6 | |
| SCHEMBL1022347 | 0.81 | CPB2 (0.40) | CPB2GSRCA14HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |