Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 1/20 | 0.31 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946851 | 0.91 | MMP2 (0.33) | MGLLMMP2MMP9ANPEPLTA4H | |
| SCHEMBL6986302 | 0.90 | MMP2 (0.34) | MGLLMMP2MMP9ANPEPLTA4H | |
| SCHEMBL6988780 | 0.90 | MMP2 (0.34) | MGLLMMP2MMP9ANPEPLTA4H | |
| SCHEMBL6945796 | 0.90 | MMP2 (0.31) | MGLLMMP2MMP9ANPEPLTA4H | |
| SCHEMBL6988554 | 0.88 | MMP2 (0.32) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6987310 | 0.88 | MMP2 (0.30) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6983153 | 0.87 | MMP2 (0.32) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6984220 | 0.87 | P2RX3 (0.30) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6980542 | 0.87 | MMP2 (0.32) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL6982294 | 0.87 | MMP2 (0.30) | MMP2MMP9ANPEPLTA4HLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |