Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 7/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6399534 | 0.81 | HTR1B (0.36) | HTR1BCA2CA12SIRT2MMP9 | |
| SCHEMBL6399540 | 0.81 | HTR1B (0.36) | HTR1BCA2CA12SIRT2MMP9 | |
| SCHEMBL6605359 | 0.77 | CA2 (0.39) | HTR1BCA2CA12SIRT2MRGPRX4 | |
| SCHEMBL6400527 | 0.69 | KMT2A (0.34) | CA2MRGPRX4POLBPIN1 | |
| SCHEMBL6404097 | 0.69 | MMP2 (0.39) | HTR1BCA2CA12MRGPRX4MMP9 | |
| SCHEMBL6400988 | 0.69 | MMP2 (0.39) | HTR1BCA2CA12MRGPRX4MMP9 | |
| SCHEMBL12773195 | 0.67 | SMN1; SMN2 (0.48) | HTR1BPOLB | |
| SCHEMBL15979957 | 0.64 | CTNNB1 (0.72) | HTR1BMMP1CTNNB1WNT3ATAS1R3 | |
| SCHEMBL826624 | 0.64 | CYP2A6 (0.55) | CA2CA12 | |
| SCHEMBL463181 | 0.64 | CA2 (0.48) | HTR1BCA2CA12CTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090100-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-29 | — | — | WO | disclosed |