Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159759 | 0.82 | KMT2A (0.58) | CNR2OPRM1KMT2AMEN1KCNJ1 | |
| SCHEMBL6985924 | 0.78 | CNR2 (0.45) | CNR2OPRM1KMT2AMEN1ALDH1A1 | |
| SCHEMBL6980052 | 0.77 | F2 (0.50) | BRD4CREBBPITKALDH1A1LMNA | |
| SCHEMBL8029974 | 0.74 | ALDH1A1 (0.55) | CNR2OPRM1KMT2AMEN1KCNJ1 | |
| SCHEMBL6480997 | 0.73 | HDAC1 (0.50) | BRD4CREBBPKCNH2ITKHDAC1 | |
| SCHEMBL6985404 | 0.73 | HDAC1 (0.40) | CNR2OPRM1BRD4CREBBPKMT2A | |
| SCHEMBL7377767 | 0.71 | ALDH1A1 (0.53) | CNR2OPRM1KMT2AMEN1ALDH1A1 | |
| SCHEMBL6634205 | 0.70 | KMT2A (0.51) | CNR2OPRM1KMT2AMEN1LMNA | |
| SCHEMBL6637649 | 0.69 | KCNJ1 (0.53) | KMT2AMEN1KCNJ1KCNH2ALDH1A1 | |
| SCHEMBL8029881 | 0.69 | KCNJ1 (0.46) | CNR2OPRM1KMT2AMEN1KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220844-B1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-04-09 | — | — | EP | disclosed |
| US-6365584-B1 | FOR PROPHYLAXIS AND THERAPY OF INFLAMMATORY AND/OR ALLERGIC DISEASES, LUNG FIBROSIS, FIBROSING ALVEOLITIS AND SCARRING, COLLAGENOSES SUCH AS LUPUS ERYTHEMATODES AND SCLERODERMIA AS WELL AS ARTERIOSCLEROSIS, PSORIASIS AND NEOPLASM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-04-02 | — | — | US | disclosed |