Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444860 | 0.78 | CYP2A6 (0.44) | CYP2A6KDM4EMAPTALDH1A1HTT | |
| SCHEMBL6975978 | 0.77 | CYP2A6 (0.44) | CYP2A6KDM4EMAPTALDH1A1HTT | |
| SCHEMBL6980313 | 0.77 | CYP2A6 (0.43) | CYP2A6KDM4EMAPTALDH1A1HTT | |
| SCHEMBL31280833 | 0.77 | CYP2A6 (0.43) | CYP2A6 | |
| SCHEMBL6973728 | 0.77 | CYP2A6 (0.43) | CYP2A6KDM4EMAPTALDH1A1HTT | |
| SCHEMBL21625562 | 0.73 | CYP2A6 (0.43) | CYP2A6TDP1MEN1LMNATHRB | |
| SCHEMBL7067241 | 0.73 | CA1 (0.42) | CYP2A6KDM4EMAPTALDH1A1GAA | |
| SCHEMBL5317362 | 0.73 | MAPT (0.36) | CYP2A6KDM4EMAPTALDH1A1HTT | |
| SCHEMBL2263913 | 0.72 | CYP2A6 (0.57) | CYP2A6KDM4EMAPTALDH1A1TDP1 | |
| SCHEMBL27339818 | 0.72 | CYP2A6 (0.39) | CYP2A6ALDH1A1GAATDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020427-B1 | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO LTD (JP) | 2003-10-01 | — | — | EP | disclosed |
| EP-1223169-A1 | Agent for potentiating nerve growth factor activity containg 1,2-ethanediol derivate or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-07-17 | — | — | EP | disclosed |
| EP-0790246-B1 | POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-6103754-A | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2000-08-15 | — | — | US | disclosed |
| EP-1020427-A1 | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |
| US-6034119-A | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2000-03-07 | — | — | US | disclosed |
| US-5968935-A | ADMINISTERING TO TREAT NERVOUS SYSTEM DISORDERS | TOYAMA CHEMICAL CO.., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| US-5932620-A | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-03 | — | — | US | disclosed |
| US-5922721-A | USE IN TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S CHOREA, AMYOTROPHIC LATERAL SCLEROSIS AND TRAUAMTIC NERVE INJURIES | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-07-13 | — | — | US | disclosed |
| US-5807887-A | COGNITION ACTIVATOR; ALZHEIMER*S, HUNTINGTON DISEASE | TOYAMA CHEMICAL CO., LTD. (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0790246-A1 | POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-08-20 | — | — | EP | disclosed |