Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.63 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5842459 | 0.92 | HTR7 (0.55) | HTR7P2RX7ABCB1HTR6SIGMAR1 | |
| Fumaric Acid SCHEMBL5842464 | 0.92 | HTR7 (0.55) | HTR7P2RX7ABCB1HTR6SIGMAR1 | |
| SCHEMBL6978580 | 0.84 | HTR7 (0.88) | HTR7ABCB1HTR6SIGMAR1 | |
| SCHEMBL6975705 | 0.82 | HTR7 (0.64) | HTR7ABCB1HTR6SIGMAR1 | |
| SCHEMBL6982210 | 0.82 | HTR7 (0.68) | HTR7P2RX7ABCB1HTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5841735 | 0.82 | HTR7 (0.63) | HTR7ABCB1HTR6SIGMAR1 | |
| SCHEMBL5842531 | 0.82 | ABCB1 (0.80) | HTR7P2RX7ABCB1HTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5840985 | 0.81 | ABCB1 (0.78) | HTR7P2RX7ABCB1HTR6SIGMAR1 | |
| SCHEMBL6984967 | 0.79 | ABCB1 (0.76) | HTR7P2RX7ABCB1HTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5840496 | 0.78 | ABCB1 (0.74) | HTR7P2RX7ABCB1HTR6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |