Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.71 |
| ▸ | MAOA | P21397 | 3/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.68 |
| ▸ | CES2 | O00748 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 5/20 | 0.62 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | MIF | P14174 | 3/20 | 0.58 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28927347 | 0.93 | MAOB (0.78) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL30412163 | 0.93 | MAOB (0.78) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL6990912 | 0.92 | MAOB (0.84) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL30413650 | 0.92 | MAOB (0.84) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL28927416 | 0.92 | MAOB (0.84) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL29038295 | 0.85 | MAOB (0.70) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL29038299 | 0.85 | MAOB (0.70) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL29038289 | 0.85 | CES2 (0.80) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL29038294 | 0.85 | CES2 (0.80) | MAOBMAOACYP19A1CES2ACHE | |
| SCHEMBL30413652 | 0.84 | MAOB (0.76) | MAOBMAOACYP19A1CES2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682919-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160355459-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2016-12-08 | — | — | US | disclosed |
| US-9439877-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2016-09-13 | — | — | US | disclosed |
| US-20160113889-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2016-04-28 | — | — | US | disclosed |
| US-9127016-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-09-08 | — | — | US | disclosed |
| US-20120122992-A1 | SMALL MOLECULE INHIBITORS OF Dusp6 AND USES THEREFOR | University of Pittsburgh-Of the Commonwealth Syste (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160113889-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | DUSP26, DUSP6, DUSP2 | MAOB 4129/4885MAOA 4194/4885CYP19A1 4462/4885 |
| US-20160355459-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | DUSP26, DUSP6, DUSP2 | MAOB 4129/4885MAOA 4194/4885CYP19A1 4462/4885 |
| US-20120122992-A1 | SMALL MOLECULE INHIBITORS OF Dusp6 AND USES THEREFOR | DUSP26, DUSP6, DUSP2 | MAOB 4129/4885MAOA 4194/4885CYP19A1 4462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.