SCHEMBL6984804

SCHEMBL6984804

N#Cc1ccc(CCC(=O)N2CCCc3cc(NCC(=O)c4ccc(Cl)cc4)ccc32)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 3/20 0.45
IDO1 P14902 2/20 0.45
TP53 P04637 1/20 0.43
HDAC1 Q13547 4/20 0.43
HDAC6 Q9UBN7 4/20 0.43
HDAC8 Q9BY41 3/20 0.43
AVPR2 P30518 2/20 0.41
CNR1 P21554 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
NCOR2 Q9Y618 1/20 0.39
DRD2 P14416 1/20 0.39
DRD4 P21917 1/20 0.39
FPR1 P21462 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6981983 0.91 RAB9A (0.46) TP53HDAC1HDAC6HDAC8FPR1
Hydrochloric Acid SCHEMBL6985331 0.87 KCNH2 (0.45) KCNH2IDO1TP53HDAC1HDAC6
SCHEMBL6984731 0.83 TP53 (0.45) TP53HDAC1HDAC6HDAC8AVPR2
SCHEMBL6984755 0.83 TP53 (0.56) TP53DRD2KDM4EALDH1A1LMNA
SCHEMBL7409209 0.82 IDO1 (0.60) KCNH2IDO1TP53HDAC1HDAC6
SCHEMBL6976282 0.82 TP53 (0.44) TP53HDAC1HDAC6HDAC8AVPR2
SCHEMBL6986432 0.81 TP53 (0.48) TP53HDAC1HDAC6HDAC8AVPR2
SCHEMBL6976631 0.81 HSD17B3 (0.46) TP53FPR1FPR2ALDH1A1
SCHEMBL7958965 0.81 IDO1 (0.45) KCNH2IDO1TP53HDAC1HDAC6
SCHEMBL7958782 0.81 IDO1 (0.45) KCNH2IDO1TP53HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991624-B1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2003-11-19 EP disclosed
US-6300342-B1 FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION BOEHRINGER INGELHEIM PHARM KG (DE) 2001-10-09 US disclosed
EP-0991624-A1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT Boehringer Ingelheim Pharma KG (DE) 2000-04-12 EP disclosed
WO-1999000371-A1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-01-07 WO disclosed