Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 6/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | FLT1 | P17948 | 4/20 | 0.36 |
| ▸ | FLT4 | P35916 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | KIF5B | P33176 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984858 | 0.80 | KDR (0.45) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7619208 | 0.76 | KDR (0.44) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5828489 | 0.76 | EGFR (0.53) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5828485 | 0.76 | EGFR (0.53) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5828856 | 0.72 | KDR (0.48) | KDREGFRFLT1FLT4RET | |
| SCHEMBL5828858 | 0.72 | KDR (0.48) | KDREGFRFLT1FLT4RET | |
| SCHEMBL4593476 | 0.71 | ENPP1 (0.59) | KITKDREGFRFGFR1FLT1 | |
| SCHEMBL4590452 | 0.71 | ENPP1 (0.59) | KITKDREGFRFGFR1FLT1 | |
| SCHEMBL5829043 | 0.71 | EPHA2 (0.52) | KITKDREPHA2EPHB4 | |
| SCHEMBL5829045 | 0.71 | EPHA2 (0.52) | KITKDREPHA2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |