Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 2/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27980382 | 0.81 | KDM4E (1.00) | KDM4ESMN1; SMN2HTTLMNAANPEP | |
| SCHEMBL3393821 | 0.81 | KDM4E (0.74) | KDM4ESMN1; SMN2HTTTP53LMNA | |
| SCHEMBL30777623 | 0.79 | KDM4E (0.71) | KDM4ESMN1; SMN2HTTTP53LMNA | |
| SCHEMBL2244729 | 0.77 | TP53 (0.52) | KDM4ESMN1; SMN2HTTTP53LMNA | |
| SCHEMBL24715431 | 0.77 | KDM4E (0.68) | KDM4ESMN1; SMN2HTTLMNAANPEP | |
| SCHEMBL3154036 | 0.77 | KDM4E (0.68) | KDM4ESMN1; SMN2HTTTP53LMNA | |
| SCHEMBL4611607 | 0.77 | KDM4E (0.68) | KDM4ESMN1; SMN2HTTTP53LMNA | |
| SCHEMBL16822346 | 0.77 | KDM4E (0.68) | KDM4ESMN1; SMN2HTTLMNAANPEP | |
| SCHEMBL23132214 | 0.77 | KDM4E (0.68) | KDM4ESMN1; SMN2HTTLMNAANPEP | |
| SCHEMBL1153017 | 0.77 | KDM4E (0.68) | KDM4ESMN1; SMN2HTTLMNAANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268434-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074784-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-β PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |