Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 16/20 | 0.61 |
| ▸ | AVPR2 | P30518 | 13/20 | 0.61 |
| ▸ | AVPR1B | P47901 | 5/20 | 0.57 |
| ▸ | OXTR | P30559 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4146200 | 0.84 | AVPR1A (0.68) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL5235720 | 0.82 | AVPR1A (0.53) | AVPR1AAVPR2AVPR1B | |
| SCHEMBL5239857 | 0.81 | AVPR1A (0.52) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL5115345 | 0.81 | AVPR1A (0.53) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL6990937 | 0.80 | AVPR2 (0.61) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL6988374 | 0.80 | AVPR1A (0.58) | AVPR1AAVPR2AVPR1B | |
| SCHEMBL8797210 | 0.78 | NPC1 (0.56) | AVPR1AAVPR2AVPR1B | |
| SCHEMBL7093443 | 0.78 | ALDH1A1 (0.58) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL6203310 | 0.77 | AVPR1A (0.60) | AVPR1AAVPR2AVPR1BOXTR | |
| SCHEMBL4835299 | 0.77 | AVPR1A (0.54) | AVPR1AAVPR2AVPR1BOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0811008-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5696112-A | TREATMENT OF CONGESTIVE HEART FAILURE, CORONARY VASOCONSTRICTION | AMERICAN CYANAMID COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |