Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | KIF5B | P33176 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985649 | 0.93 | RET (0.49) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL6981911 | 0.88 | HTT (0.48) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL5828850 | 0.83 | KDM1A (0.49) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL5828851 | 0.83 | KDM1A (0.49) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL5828728 | 0.81 | EGFR (0.50) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL5828729 | 0.81 | EGFR (0.50) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL5828058 | 0.81 | KDR (0.48) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL5828053 | 0.81 | KDR (0.48) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL4689455 | 0.80 | EGFR (0.58) | EGFRHTTHPGDKDM4ELMNA | |
| SCHEMBL5827885 | 0.75 | RET (0.47) | EGFRHTTHPGDRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |