Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 12/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828058 | 1.00 | KDR (0.48) | KDREPHA2EPHB4EGFRNSD2 | |
| SCHEMBL5828878 | 0.94 | KDR (0.51) | KDREPHA2EPHB4EGFRNSD2 | |
| SCHEMBL5828880 | 0.94 | KDR (0.51) | KDREPHA2EPHB4EGFRNSD2 | |
| SCHEMBL5828988 | 0.89 | KDR (0.46) | KDREPHA2EPHB4EGFR | |
| SCHEMBL5828980 | 0.89 | KDR (0.46) | KDREPHA2EPHB4EGFR | |
| SCHEMBL7089596 | 0.85 | KDR (0.48) | KDREPHA2EPHB4EGFRNSD2 | |
| SCHEMBL6985326 | 0.81 | EGFR (0.49) | KDREGFREHMT2KDM4ELMNA | |
| SCHEMBL4689455 | 0.76 | EGFR (0.58) | KDREGFRIRAK1IRAK4KDM4E | |
| SCHEMBL6981911 | 0.75 | HTT (0.48) | KDREGFRKDM4ELMNAHPGD | |
| SCHEMBL6980090 | 0.74 | EGFR (0.60) | KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |