Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.49 |
| ▸ | KIF5B | P33176 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.45 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981911 | 0.94 | HTT (0.48) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL6985326 | 0.93 | EGFR (0.49) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL5827885 | 0.81 | RET (0.47) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL5827881 | 0.81 | RET (0.47) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL5828872 | 0.79 | HTT (0.48) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL5828868 | 0.79 | HTT (0.48) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL5828880 | 0.78 | KDR (0.51) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL5828878 | 0.78 | KDR (0.51) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL5828851 | 0.75 | KDM1A (0.49) | RETKIF5BHTTHPGDALDH1A1 | |
| SCHEMBL5828850 | 0.75 | KDM1A (0.49) | RETKIF5BHTTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |