Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 6/20 | 0.45 |
| ▸ | HRH1 | P35367 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986404 | 0.88 | POLB (0.48) | MAPTRAB9AHRH2HRH1SMN1; SMN2 | |
| SCHEMBL12480371 | 0.82 | GPR119 (0.56) | MAPTOGAPTPN11 | |
| SCHEMBL30121712 | 0.80 | MEN1 (0.45) | MAPTHRH2HRH1SMN1; SMN2LMNA | |
| SCHEMBL24881185 | 0.79 | OGA (0.54) | MAPTOGALMNAPOLBMEN1 | |
| SCHEMBL15038302 | 0.79 | HDAC3 (0.56) | MAPTOGALMNAPOLBHTT | |
| SCHEMBL12952642 | 0.79 | POLB (0.54) | MAPTOGARAB9ASMN1; SMN2LMNA | |
| SCHEMBL6984326 | 0.79 | MAPT (0.57) | MAPTOGARAB9ASMN1; SMN2LMNA | |
| SCHEMBL20552861 | 0.78 | OGA (0.53) | MAPTOGALMNAPOLBMEN1 | |
| SCHEMBL25678417 | 0.78 | MAPT (0.56) | MAPTOGARAB9ASMN1; SMN2LMNA | |
| SCHEMBL9482270 | 0.77 | MAPT (0.51) | MAPTRAB9ASMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | claimed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | claimed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | claimed |