Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 6/20 | 0.47 |
| ▸ | HRH1 | P35367 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985360 | 0.88 | MAPT (0.48) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL30121712 | 0.82 | MEN1 (0.45) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL6984337 | 0.79 | MEN1 (0.45) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL15344316 | 0.78 | HDAC1 (0.55) | POLBSMN1; SMN2HRH2HRH1MEN1 | |
| SCHEMBL3605523 | 0.76 | GPR119 (0.59) | POLBLMNAPTPN11ALDH1A1MAPT | |
| SCHEMBL28615895 | 0.76 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL9405372 | 0.76 | POLB (0.73) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL29741845 | 0.75 | HRH3 (0.53) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL1459682 | 0.75 | MAPT (0.57) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL29891203 | 0.75 | ME2 (0.40) | POLBSMN1; SMN2LMNAHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | claimed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | claimed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | claimed |